Gamma-aminobutyric acid reuptake inhibitors

What are Gamma-aminobutyric acid reuptake inhibitors?

Gamma-Aminobutyric acid (GABA) reuptake inhibitors are analogs of gamma-Aminobutyric acid that bind to gamma-aminobutyric acid transporters and inhibit GABA reuptake. This increases extracellular levels of GABA and enhances GABA mediated synaptic activity in the brain.

Gamma-Aminobutyric acid reuptake inhibitors are used as anticonvulsant agents to treat epilepsy.

A GABA reuptake inhibitor (GRI) is a type of drug which acts as a reuptake inhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking the action of the gamma-Aminobutyric acid transporters (GATs).

GABA receptor antagonists are drugs that inhibit the action of GABA. In general these drugs produce stimulant and convulsant effects, and are mainly used for counteracting overdoses of sedative drugs. Examples include bicuculline, securinine and metrazol, and the benzodiazepine GABAA receptor antagonist flumazenil.

The γ-aminobutyric acid (GABA) reuptake inhibitors retigabine, stiripentol, and tiagabineare GABA analogues that bind to GABA transporters. By inhibiting the GABA reuptake, they increase extracellular GABA levels and thereby enhance GABA-mediated synaptic activity in the brain.

A GABA reuptake inhibitor is a substance that blocks the GABA transporter in the brain, leading to increased availability of GABA for binding to receptors. It is used as an adjunctive treatment for partial seizures.