Growth hormone receptor blockers

What are Growth hormone receptor blockers?

Growth hormone receptor blockers are drugs that bind to the growth hormone receptor and make it non-functional. As a result growth hormone cannot exert its effect. These agents are used to control acromegaly.

Summary. Pegvisomant is the first clinically available GHR antagonist. It prevents proper GHR dimerization and therefore inhibits GH action.

These inhibitors include the first-generation SRLs, octreotide and lanreotide, and the second-generation SRLs, pasireotide, octreolin, and somatoprim. Currently, SRLs are used to treat acromegaly and neuroendocrine tumors.

Growth hormone receptor antagonist pegvisomant and its role in the medical therapy of growth hormone excess. Pegvisomant is a growth-hormone (GH) receptor antagonist that prevents the formation of the active heterotrimer of the dimerised GH receptor and the GH molecule necessary for downstream signal transduction.

Growth hormone, IGF-1, and insulin sometimes antagonize or amplify each other’s direct actions. In this interplay, for translating growth hormone actions into IGF-1 production, the production of endogenous insulin that reaches the liver via the portal vein is an essential factor.

Abscisic acid is a plant hormone that inhibits growth in plants. It is synthesized in leaves. It promotes senescence i.e. wilting or fall of leaves. Abscisic acid also inhibits seed germination and development.