Immune globulins

What are Immune globulins?

In healthy individuals immune globulins are made by plasma cells when exposed by an immunogen such as a virus. Immune globulins act as antibodies against an infection. They are made up of different classes and subclasses of molecules. The immune globulin used for therapeutic purposes is made from healthy human blood that has a high level of antibodies. Immune globulins are given to those with a weak immune system to strengthen or act as the body’s natural immune system. It decreases the risk of infection in the immunocompromised patients, who are unable to make antibodies themselves.

Intravenous immune globulin (“IVIG”) is a product made up of human antibodies from blood donors that can be given intravenously (through a vein). It may be referred to as a “plasma derivative” because it is made from the blood plasma (the liquid part that does not contain any cells).

The following are five types of immunoglobulins in humans:

IgM.
IgG.
IgA.
IgE.
IgD

IgG – Immune defense and passive immunity. IgM – Early response and complement activation. IgA – Mucosal protection and neonatal defense. IgE – Allergies and parasite defense. IgD – B and T cell regulation.

Globulins are a group of proteins in your blood. Some globulins are made by your liver. Others are made by your immune system. Globulins play an important role in liver and kidney function, blood clotting, and fighting infection.