Angiotensin II inhibitors with thiazides 

Angiotensin II inhibitors with thiazides is a combination medicine containing both an angiotensin II inhibitor and a thiazide. The angiotensin II inhibitor stops the activation of the angiotensin II receptor which results in vasodilatation, a reduction of aldosterone production and reduced vasopressin. These effects cause the reduction of blood pressure. Thiazide diuretics decrease active re-absorption of sodium and chloride ions by inhibiting the sodium/chloride co-transporter in the distal convoluted tubule. This causes an increase in urine production (diuresis) and results in a decrease in blood volume and a reduction in blood pressure.

An ACE inhibitor and thiazide combination is a drug combination used to treat hypertension (high blood pressure). They are given by mouth. ACE inhibitors reduce the activity of angiotensin-converting enzyme (ACE) which produces angiotensin II, a hormone that constricts blood vessels.

Angiotensin-converting enzyme inhibitor (ACEI)/hydrochlorothiazide (HCTZ) combos are a type of antihypertensive drug used in the management of high blood pressure. ACEI blocks the angiotensin-converting enzyme, which is responsible for converting angiotensin I into angiotensin II.