Anticoagulant reversal agents 

Anticoagulant reversal agents are required when anticoagulant therapy needs to be reversed or neutralized in situations when there are bleeding complications, an overdose of anticoagulant therapy or unplanned surgery is required.

Reversal or “antidote” drugs, such as flumazenil and naloxone, are often used in unintentional overdose situations involving significant benzodiazepine- and/or opioid-induced respiratory depression.

It is important to differentiate between emergencies on the basis of severity of bleeding and urgency of reversal of warfarin anticoagulation. Anticoagulation can be reversed with 2.5 to 5 mg of vitamin K administered intravenously in a patient taking warfarin who requires urgent surgery.

Anticoagulants are medicines that help prevent blood clots. They’re given to people at a high risk of getting clots, to reduce their chances of developing serious conditions such as strokes and heart attacks. A blood clot is a seal created by the blood to stop bleeding from wounds.