Antihypertensive combinations 

Combination therapy provides greater antihypertensive power than the use of high doses of monotherapy, adding several mechanisms of action that block various pathways of increased blood pressure, in addition to providing greater protection to target organs than monotherapy, and reduced potential for side effects.

BB can be combined with vasodilators and alpha blockers with good therapeutic benefit. BB with angiotensin converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB) is not an ideal combination as both the drugs act in the renin-angiotensin system.

The combination of olmesartan and amlodipine in a single tablet effectively reduces BP and attenuates the adverse events of the amlodipine component in hypertensive patients.