Antiadrenergic agents (peripheral) with thiazides
What are Antiadrenergic agents (peripheral) with thiazides?
Alpha adrenoreceptor antagonists prevent the stimulation of alpha-adrenergic receptors at the nerve endings of the sympathetic nervous system. Alpha1-selective antagonists are used as cardiovascular agents as they block the alpha adrenoreceptors on the vascular smooth muscle and widen the arteries, causing vasodilatation and a reduction in blood pressure.
Thiazide diuretics decrease active re-absorption of sodium and chloride ions by inhibiting the sodium/chloride co-transporter in the distal convoluted tubule. They also increase potassium ion loss. Thiazide diuretics decrease the blood volume by diuresis and are used to decrease blood pressure. The combination of a peripherally acting antiadrenergic agents with thiazide diuretics is used to treat hypertension.
Centrally acting antiadrenergic agents make the heart beat slower and with less force, and relax the blood vessels. All these actions lead to a decrease blood pressure. Centrally acting antiadrenergic agents are used to treat hypertension.
Antiadrenergic drugs can be classified according to their specificity for the different receptors. Receptors , with the major classes including selective beta-1 receptor. Receptors blockers, nonselective beta-blockers.
An alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines.





