Antiparkinson agents 

Levodopa: this drug is the most effective medication to control the symptoms of Parkinson’s disease. It is absorbed by the nerve cells in your brain and is converted to dopamine. Levodopa is usually combined with a peripheral dopa-decarboxylase inhibitor such as benserazide or carbidopa.

The antiparkinsonian effect of anticholinergics was discovered in 1867 (Ordenstein 1867), and for nearly a century, they remained the only drugs available for the symptomatic treatment of Parkinson´s disease.

Ergoline-derived dopamine agonists (bromocriptine, cabergoline and pergolide) can cause pulmonary and retroperitoneal fibrosis and other ergot adverse effects such as digital vasospasm and erythromelalgia.