Beta blockers with thiazides

What are Beta blockers with thiazides?

Beta blockers act by blocking the beta adrenergic receptors in the sympathetic nervous system which results a reduction in systolic pressure, heart rate, cardiac contractility and output. Beta blockers are routinely used to treat hypertension and to reduce the risk of cardiovascular disease and stroke. Thiazide diuretics decrease active re-absorption of sodium and chloride ions by inhibiting the sodium/chloride co-transporter in the distal convoluted tubule. They also increase potassium ion loss. Thiazide diuretics decrease the blood volume by diuresis and are used in the treatment of hypertension. The combination of a beta blockers with thiazide diuretic results in additive antihypertensive effect compared to using either agent alone.

Beta-blocker/thiazide diuretic combos are a combination of two antihypertensive drugs beta-blockers and thiazide diuretics. Beta-blocker/thiazide diuretic combos lower the blood pressure by removing excess water and salt from the body and slowing the heart rate.

Hydrochlorothiazide is a thiazide diuretic (water pill). Metoprolol is a beta-blocker. Hydrochlorothiazide and metoprolol is a combination medicine used to treat high blood pressure (hypertension).

β-Blockers combine well with DHP CCBs and α-blockers. Although efficacy is good with diuretic agents, there is an increased risk of metabolic disturbance. There is a risk of bradycardia and heart block with non-DHP CCBs particularly with the use of verapamil.