ACE inhibitors with thiazides

What are ACE inhibitors with thiazides?

ACE inhibitors with thiazides is a combination medicine containing both an angiotensin-converting-enzyme inhibitor (ACE inhibitor) and a thiazide.

An ACE inhibitor blocks the angiotensin converting enzyme from converting angiotensin I to angiotensin II. This results in a decrease in angiotensin II causing vasodilation and therefore a reduction in blood pressure.

Thiazide diuretics decrease active re-absorption of sodium and chloride ions by inhibiting the sodium/chloride co-transporter in the distal convoluted tubule. This causes an increase in urine production (diuresis) and results in a decrease in blood volume and a reduction in blood pressure.

Zestoretic

Generic name: hydrochlorothiazide and lisinopril [ HYE-droe-KLOR-oh-THYE-a-zide-and-lye-SIN-oh-pril ]Drug class: ACE inhibitors with thiazides What is Zestoretic? Zestoretic contains a combination of hydrochlorothiazide and lisinopril. Hydrochlorothiazide...

August 26, 2025