What are Adamantane antivirals?
Adamantane antivirals are only active against influenza A virus, an RNA virus, but has no action against influenza B virus. A viral membrane protein, M2, functions as an ion channel at two stages of the viral replication within the host cell. These stages are the fusion of viral membrane and endosome membrane, and the assembly and release of new virions. Adamantane antivirals block this ion channel.
Adamantanes. The adamantanes include the oral medications amantadine and rimantadine. These drugs block the M2 ion channel on influenza A viruses that maintains the acidity of the Golgi microenvironment and permits virus uncoating.
Adamantane itself enjoys few applications since it is merely an unfunctionalized hydrocarbon. It is used in some dry etching masks and polymer formulations. In solid-state NMR spectroscopy, adamantane is a common standard for chemical shift referencing.
Amantadine interferes with the release of infectious viral nucleic acid into the host cell through interaction with the transmembrane domain of the M2 protein of the virus. It also appears to prevent virus assembly during replication in some cases.
Pronunciation: a-MAN-ta-deenGeneric name: amantadineBrand names: Gocovri, Osmolex ER, SymmetrelDrug classes: Adamantane antivirals , Dopaminergic antiparkinsonism agents What is amantadine? Amantadine is an antiviral medicine that blocks the...
Aldosterone receptor antagonists / Letter - A / Potassium-sparing diuretics
December 24, 2025
Laxatives / Letter - M / Minerals and electrolytes / Miscellaneous anticonvulsants
September 6, 2025
Boost your medical knowledgewith our comprehensive Medical Quiz Bank – designed for pre-medical, medical, and postgraduate students.
Practice smarter, master exams faster, and stay ahead in your medical journey!
Discover your ultimate medical store, serving medical students, doctors, healthcare professionals, the general public, and store owners. We provide a wide range of medical supplies, equipment, and gadgets to meet all your needs. Whether you’re stocking your clinic, looking for study tools, or shopping for everyday health products, our platform makes it easy, reliable, and convenient. Store owners can also showcase their products and reach a wide audience. Everything medical, all in one place!
