What is Imitrex?

Imitrex is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.

Imitrex is available as oral tablets, a nasal spray, and as an injection. It used to treat migraine headaches in adults. Imitrex will only treat a headache. It will not prevent headaches or reduce the number of attacks.

Imitrex should not be used to treat a common tension headache or a headache that causes loss of movement on one side of your body. Use this medicine only if your condition has been confirmed by a doctor as migraine headaches.

Warnings

You should not use Imitrex if you have uncontrolled high blood pressure, heart problems, certain heart rhythm disorders, a history of heart attack or stroke, or circulation problems that cause a lack of blood supply within the body.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Also tell your doctor if you are taking an antidepressant such as citalopram (Celexa), desvenlafaxine (Pristiq), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor).

Imitrex will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

Do not use Imitrex within 24 hours before or after using any other migraine headache medicine.

Before taking this medicine

You should not use Imitrex if you are allergic to sumatriptan, or if you have ever had:

• heart problems, or a stroke (including “mini-stroke”);
• coronary artery disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart;
• circulation problems affecting your legs, arms, stomach, intestines, or kidneys;
• a heart disorder called Wolff-Parkinson-White syndrome;
• uncontrolled high blood pressure;
• severe liver disease; or
• a headache that seems different from your usual migraine headaches.

Do not use Imitrex if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, serious infections, or prevention of nausea and vomiting. These medicines may interact with sumatriptan and cause a serious condition called serotonin syndrome.

To make sure Imitrex is safe for you, tell your doctor if you have ever had:

• liver or kidney disease;
• epilepsy or other seizure disorder;
• high blood pressure, a heart rhythm disorder; or
• risk factors for coronary artery disease (such as diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, or being older than 40 and a man).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Sumatriptan can pass into breast milk. Do not breast-feed within 12 hours after using Imitrex. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

Imitrex is not approved for use by anyone younger than 18 years old.

How should I use Imitrex?

Use Imitrex as soon as you notice headache symptoms. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You may receive your first dose in a hospital or clinic setting to quickly treat any serious side effects.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Take a Imitrex tablet whole with a full glass of water. Do not split the tablet.

After using Imitrex: If your headache does not completely go away, or goes away and comes back, use a second dose if it has been at least 2 hours since your first dose.

Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks.

Do not take more than 200 milligrams of oral Imitrex within 24 hours.

Do not use more than 40 milligrams of Imitrex nasal spray within 24 hours.

Call your doctor if your symptoms do not improve, or if you have more than 4 headaches in one month (30 days).

Store at room temperature away from moisture, heat, and light. Do not store in a refrigerator. Do not freeze.

Dosing information

Usual Adult Dose for Migraine:

Use only after a clear diagnosis of migraine has been established

Oral:
Initial dose: 25 mg, 50 mg, or 100 mg orally, once
-If some response to first dose occurs, a second dose may be administered at least 2 hours after first dose if needed
-Oral doses of 50 and 100 mg may provide greater relief than 25 mg; however, a 100 mg dose may not provide greater effect than a 50 mg dose
Maximum dose: 200 mg per 24 hours

Intranasal:
Nasal spray: Initial dose: 5 mg, 10 mg, or 20 mg into one nostril, once
-Administer the 5 and 20 mg doses as a single spray in 1 nostril; the 10 mg dose may be administered as 5 mg into each nostril
-If some response to first dose occurs, a second dose may be administered at least 2 hours after first dose if needed
Maximum dose: 40 mg per 24 hours

Comments:
-Treatment should be started at the first sign of a migraine headache, or associated symptoms such as nausea, vomiting, or photophobia; this drug should not be used for migraine prophylaxis.
-Higher doses may have a greater effect, but also carry a greater risk of adverse reactions.
-The safety of treating an average of more than 4 headaches in a 30 day period has not been established.

Use: For the acute treatment of migraine with or without aura.

What happens if I miss a dose?

Since Imitrex is used when needed, it does not have a daily dosing schedule. Call your doctor if your symptoms do not improve after using this medicine.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line .

Overdose symptoms may include tremors, skin redness in your arms or legs, weakness, loss of coordination, breathing problems, blue-colored lips or fingernails, vision problems, or a seizure (convulsions).

What should I avoid while using Imitrex?

Do not use Imitrex within 24 hours before or after using another migraine headache medicine, including:

• sumatriptan injection, almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, zolmitriptan; or
• ergot medicine such as dihydroergotamine, ergotamine, ergonovine, or methylergonovine.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Imitrex side effects

Get emergency medical help if you have signs of an allergic reaction to Imitrex: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Imitrex and call your doctor at once if you have:

• sudden and severe stomach pain and bloody diarrhea;
• severe chest pain, shortness of breath, irregular heartbeats;
• a seizure (convulsions);
• severe headache, blurred vision, pounding in your neck or ears;
• blood circulation problems in your legs or feet – cramps, tight or heavy feeling, numbness or tingling, muscle weakness, burning pain, cold feeling, color changes (pale or blue), hip pain;
• heart attack symptoms – chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
• high levels of serotonin in the body – agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, vomiting, diarrhea; or
• signs of a stroke – sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.

Common Imitrex side effects may include:

• pain or tight feeling in your chest, throat, or jaw;
• pressure or heavy feeling in any part of your body;
• numbness or tingling, feeling hot or cold;
• dizziness, drowsiness, weakness;
• unusual or unpleasant taste in your mouth after using the nasal medicine;
• pain, burning, numbness, or tingling in your nose or throat after using the nasal medicine; or
• runny or stuffy nose after using the nasal medicine.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA .

What other drugs will affect Imitrex?

Using Imitrex while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called “serotonin syndrome,” which can be fatal. Tell your doctor if you also use:

• medicine to treat depression or a psychiatric disorder;
• medicine for Parkinson’s disease;
• medicine for serious infections;
• herbal products;
• stimulant medicine;
• opioid medicine; or
• medicine to prevent nausea and vomiting.

What is naratriptan?

Naratriptan is a headache medicine that narrows blood vessels around the brain. Naratriptan also reduces substances in the body that can trigger headache pain, sensitivity to light and sound, and other migraine symptoms.

Naratriptan is used to treat migraine headaches. Naratriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

Naratriptan should not be used to treat a common tension headache, a headache that causes loss of movement on one side of your body, or any headache that seems to be different from your usual migraine headaches. Use naratriptan only if your condition has been confirmed by a doctor as migraine headaches.

Naratriptan may also be used for purposes not listed in this medication guide.

Naratriptan side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Naratriptan may cause serious side effects. Stop using naratriptan and call your doctor at once if you have:

• fast or pounding heartbeats;
• numbness or tingling and a pale or blue-colored appearance in your fingers or toes;
• pain or heavy feeling in your legs, hip pain, burning pain in your feet;
• sudden and severe stomach pain, bloody diarrhea, constipation, fever, weight loss;
• dangerously high blood pressure–severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats, seizure;
• heart attack symptoms–chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
• high levels of serotonin in the body–agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting; or
• signs of a stroke–sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.

Common side effects of naratriptan may include:

• dizziness, drowsiness;
• feeling weak or tired;
• numbness or tingling;
• flushing (warmth, redness, or tingly feeling);
• nausea; or
• pain or tightness in your jaw, neck, or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA

Warnings

You should not use naratriptan if you have uncontrolled high blood pressure, heart problems, certain heart rhythm disorders, severe liver or kidney disease, a history of heart attack or stroke, or circulation problems that cause a lack of blood supply within the body.

Do not take naratriptan within 24 hours before or after using another migraine headache medicine.

Before taking this medicine

You should not use this medicine if you are allergic to naratriptan, or if you have:

• severe or uncontrolled high blood pressure;
• past or present heart problems;
• history of coronary artery disease, heart attack, or stroke, including “mini-stroke”;
• Wolff-Parkinson-White syndrome or other heart rhythm disorder;
• a blood vessel disorder or circulation problems that cause a lack of blood supply within the body;
• severe liver or kidney disease; or
• a headache that seems different from your usual migraine headaches.

To make sure naratriptan is safe for you, tell your doctor if you have:

• liver or kidney disease;
• high blood pressure, a heart rhythm disorder; or
• coronary heart disease (or risk factors such as diabetes, menopause, smoking, being overweight, having high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether naratriptan passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Do not give this medicine to anyone younger than 18.

How should I use naratriptan?

Your doctor may want to give your first dose of naratriptan in a hospital or clinic setting to quickly treat any serious side effects that occur.

Follow all directions on your prescription label. Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks.

Take naratriptan as soon as you notice migraine symptoms.

Take 1 tablet whole with a full glass of water.

After taking a tablet: If your headache does not go away completely, or if it goes away and comes back, call your doctor before taking a second tablet.

Do not take the second tablet until at least 4 hours have passed since you took the first tablet. Do not take more than 5 milligrams (mg) of naratriptan in 24 hours.

If your symptoms have not improved after taking 2 tablets in 24 hours, contact your doctor before taking any more tablets.

Tell your doctor if you have more than four headaches in one month (30 days).

Naratriptan can raise blood pressure to dangerous levels. Your blood pressure may need to be checked often while you are using this medicine. If you use naratriptan long-term, your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).

Store at room temperature away from moisture, heat, and light.

Naratriptan dosing information

Usual Adult Dose for Migraine:

Use only after a clear diagnosis of migraine has been established

Initial dose: 1 mg or 2.5 mg orally, once
-Provided there has been some response to first dose, a second dose may be administered at least 4 hours later if migraine returns or symptoms recur.
Maximum dose: 5 mg in a 24-hour period

Comments:
-This drug should not be used to treat basilar or hemiplegic migraines because these patients are at a greater risk of stroke.
-The safety of treating an average of 4 or more migraine attacks in a 30-day period has not been established.

Use: For the acute treatment of migraine with or without aura.

What happens if I miss a dose?

Since naratriptan is used as needed, it does not have a daily dosing schedule. Call your doctor if your symptoms do not improve after using naratriptan.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line .

Overdose symptoms may include tiredness, neck stiffness, loss of coordination, or feeling light-headed.

What should I avoid while using naratriptan?

Do not take naratriptan within 24 hours before or after using another migraine headache medicine, including:

• medicines like naratriptan–almotriptan, eletriptan, frovatriptan, rizatriptan, sumatriptan, zolmitriptan, and others; or
• ergot medicine–dihydroergotamine, ergotamine, ergonovine, methylergonovine.

naratriptan may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What other drugs will affect naratriptan?

Taking naratriptan while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called “serotonin syndrome,” which can be fatal. Tell your doctor if you also use:

• medicine to treat depression;
• medicine to treat a psychiatric disorder;
• a narcotic (opioid) medication; or
• medicine to prevent nausea and vomiting.

What is Reyvow?

Reyvow is a serotonin (5-HT) 1F receptor agonist.

Reyvow is used in adults to treat migraine headaches with or without aura.

Reyvow will only treat and will not prevent migraine headache.

Warnings

Reyvow is a federally controlled substance (CV) because it contains lasmiditan that can be a target for people who abuse prescription medicines or street drugs.

Keep this medicine in a safe place to protect it from theft. Never give your Reyvow to anyone else, because it may harm them. Selling or giving away Reyvow is against the law. Tell your healthcare provider if you have ever abused or been dependent on alcohol, prescription medicines or street drugs.

Do not take more than one dose in a 24-hour period.

For at least 8 hours after taking Reyvow, do not drive and avoid other hazardous activity.

Before taking this medicine

To make sure Reyvow is safe for you, tell your doctor if you have:

• an allergy to lasmiditan;
• liver disease;
• slow heartbeats;
• high blood pressure; or
• drug addiction.

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with lasmiditan and cause a serious condition called serotonin syndrome.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of lasmiditan on the baby.

Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether lasmiditan will harm an unborn baby. However, having migraine headaches during pregnancy may cause complications such as eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating migraines may outweigh any risks to the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

How should I take Reyvow?

Take Reyvow exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Reyvow may be habit-forming. Misuse can cause addiction, overdose, or death. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

Take Reyvow soon as you notice headache symptoms.

Swallow the tablet whole and do not crush, chew, or break it.

Do not take more than one dose in a 24-hour period.

You may take this medicine with or without food.

Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks.

Call your doctor if your headache does not go away completely, or if you have more than 4 headaches in one month (30 days).

Store at room temperature away from moisture and heat.

Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Dosing information

Usual Adult Dose for Migraine:

Initial dose: 50 mg, 100 mg, or 200 mg orally once
Maximum dose: 1 dose per day

Comments:
-This drug should not be taken unless the patient can wait 8 hours or more before driving or operating machinery.
-No more than 1 dose should be taken in 24 hours; a second dose has not been shown to be effective for the same migraine attack.
-The safety of treating an average of more than 4 migraine attacks in a 30-day period has not been established.
-This drug is not indicated for the prevention of migraine attacks.

Use: For the acute treatment of migraine with or without aura.

What happens if I miss a dose?

Since Reyvow is used once when needed, it does not have a daily dosing schedule. Call your doctor if your migraine symptoms do not improve after using this medicine.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line .

What to avoid

After taking Reyvow, do not drive for at least 8 hours, and avoid other hazardous activity. Your reactions could be impaired, and you may not realize the extent of that impairment.

Drinking alcohol with this medicine can cause side effects.

Reyvow side effects

Get emergency medical help if you have signs of an allergic reaction to Reyvow: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common Reyvow side effects may include:

• dizziness, drowsiness;
• feeling tired; or
• numbness or tingling.

What is rizatriptan?

Rizatriptan is a headache medicine that narrows the blood vessels around the brain. Rizatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.

Rizatriptan is used to treat migraine headaches. Rizatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

Rizatriptan should not be used to treat a common tension headache, or a headache that causes loss of movement on one side of your body. Use rizatriptan only if your condition has been confirmed by a doctor as migraine headaches.

Rizatriptan may also be used for purposes not listed in this medication guide.

Rizatriptan side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Rizatriptan may cause serious side effects. Stop using rizatriptan and call your doctor at once if you have:

• sudden and severe stomach pain and bloody diarrhea;
• cold feeling or numbness in your feet and hands;
• severe headache, blurred vision, pounding in your neck or ears;
• heart attack symptoms–chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
• high levels of serotonin in the body–agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea; or
• signs of a stroke–sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.

Common side effects of rizatriptan may include:

• dizziness, drowsiness, feeling tired; or
• pain or a feeling of pressure in your throat or chest.

Warnings

You should not use rizatriptan if you have uncontrolled high blood pressure, heart problems, a history of heart attack or stroke, or circulation problems that cause a lack of blood supply within the body.

Do not take rizatriptan within 24 hours before or after using another migraine headache medicine.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Before taking this medicine

You should not use rizatriptan if you are allergic to it, or if you have:

• heart problems, or a stroke (including “mini-stroke”);
• coronary artery disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart;
• circulation problems affecting your legs, arms, stomach, intestines, or kidneys;
• uncontrolled high blood pressure;
• severe liver disease; or
• a headache that seems different from your usual migraine headaches.

Do not use rizatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have ever had:

• liver or kidney disease;
• heart problems, chest pain;
• shortness of breath; or
• risk factors for coronary artery disease (such as high blood pressure, high cholesterol, diabetes, menopause, smoking, a family history of coronary artery disease, being overweight, or being older than 40 and a man).

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with rizatriptan and cause a serious condition called serotonin syndrome.

Rizatriptan disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

Tell your doctor if you are pregnant or breastfeeding.

Rizatriptan is not approved for use by anyone younger than 6 years old.

How should I use rizatriptan?

Take rizatriptan as soon as you notice headache symptoms. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You may receive your first dose in a hospital or clinic setting to quickly treat any serious side effects.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Take the regular tablet whole with a full glass of water.

Remove an orally disintegrating tablet from the package only when you are ready to take the medicine. Place the tablet in your mouth and allow it to dissolve, without chewing. Swallow several times as the tablet dissolves.

After taking a tablet (for adults): If your headache does not completely go away, or goes away and comes back, take a second tablet 2 hours after the first. If your symptoms have not improved, contact your doctor before taking any more tablets.

After taking a tablet (for children ages 6 to 17): If your headache does not completely go away, or goes away and comes back, contact your doctor before taking any more tablets.

Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks.

Call your doctor if your symptoms do not improve, or if you have more than 4 headaches in one month (30 days).

Rizatriptan can raise blood pressure to dangerous levels. Your blood pressure may need to be checked often while you are using rizatriptan. If you use rizatriptan long-term, your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).

Store at room temperature away from moisture and heat.

Rizatriptan dosing information

Usual Adult Dose for Migraine:

Use only after a clear diagnosis of migraine has been established

Initial dose: 5 mg or 10 mg orally, once
-Provided there has been a response to first dose, a second dose may be administered at least 2 hours later if migraine returns
Maximum dose: 30 mg in a 24-hour period

Comments:
-The 10 mg dose may provide greater effect, however there may be a greater risk of adverse reactions.
-This drug should not be used to treat basilar or hemiplegic migraines because these patients are at a greater risk of stroke.
-The safety of treating an average of 4 or more migraine attacks in a 30-day period has not been established; the effectiveness of a second dose or subsequent doses has not been established in placebo-controlled trials.

Use: For the acute treatment of migraine with or without aura.

Usual Pediatric Dose for Migraine:

Use only after a clear diagnosis of migraine has been established

6 years or older and weight less than 40 kg:
-Initial dose: 5 mg orally once

6 years or older and weight 40 kg or greater:
-Initial dose: 10 mg orally once

Maximum: 1 dose in any 24-hour period

Comments:
-This drug should not be used to treat basilar or hemiplegic migraines because these patients are at a greater risk of stroke.
-The safety of treating an average of 4 or more migraine attacks in a 30-day period has not been established; the safety and effectiveness of more than 1 dose within 24 hours has not been established.

Use: For the acute treatment of migraine with or without aura in patients 6 years or older.

What happens if I miss a dose?

Since rizatriptan is used when needed, it does not have a daily dosing schedule. Call your doctor if your symptoms do not improve after using this medicine.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line .

What should I avoid while using rizatriptan?

Do not take rizatriptan within 24 hours before or after using another migraine headache medicine, including:

• almotriptan, eletriptan, frovatriptan, naratriptan, sumatriptan, zolmitriptan; or
• ergot medicine–dihydroergotamine, ergotamine, ergonovine, methylergonovine.

Avoid driving or hazardous activity until you know how rizatriptan will affect you. Your reactions could be impaired.

What other drugs will affect rizatriptan?

Tell your doctor about all your other medicines, especially:

• propranolol;
• an antidepressant; or
• medicine to treat a mood disorder.