What is Jublia solution?
Jublia topical solution contains efinaconazole, an antifungal medication that fights infections caused by fungus.

Jublia solution is used to treat a fungal infection of the toenail called onychomycosis.

Jublia solution is a clear, colorless to pale yellow solution supplied in a white plastic bottle with a flow-through brush applicator.

Warnings
Jublia solution is for external use only and is not for ophthalmic, oral, or intravaginal use. It is for use on toenails and immediately adjacent skin only.

Avoid pedicures, the use of nail polish, and cosmetic nail products while using Jublia.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine
You should not use Jublia if you are allergic to efinaconazole.

It is not known whether efinaconazole will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether efinaconazole topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breastfeeding a baby.

Jublia solution is not approved for use by anyone younger than 6 years old.

Jublia pregnancy and breastfeeding warnings (more detail)
How should I use Jublia solution?
Use Jublia solution exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Jublia is usually applied to affected toenails once daily for 48 weeks (approximately 11 months).

Before you apply this medicine, wash and thoroughly dry your toenails. Wait at least 10 minutes after showering, bathing, or washing the area before applying Jublia.

Apply this medicine over the entire toenail and under the tip of the nail. Allow the medicine to dry completely before putting on a sock or shoe.

After you apply Jublia solution, wait at least 10 minutes before you take a bath or shower.

Avoid getting this medicine on any other skin besides the cuticles or the skin around your toenail.

Call your doctor if your symptoms do not improve, or if they get worse while using Jublia.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses can increase your risk of infection that is resistant to medication.

Store in an upright position at room temperature, away from moisture and heat. Do not freeze.

Store in an upright position at room temperature, away from moisture and heat. Keep the bottle tightly closed when not in use. Do not freeze.

Jublia solution is flammable. Do not use near high heat or open flame. Do not smoke until the solution has completely dried on your nail.

Dosing information
Usual Adult Dose for Onychomycosis — Toenail:

Apply to affected toenail(s) once a day for 48 weeks.

Comments:
-The integrated flow-through brush applicator should be used.
-The toenail, toenail folds, toenail bed, hyponychium, and undersurface of the toenail plate should be completely covered.

Use: For the topical treatment of onychomycosis of the toenail(s) due to Trichophyton rubrum and T mentagrophytes

Usual Pediatric Dose for Onychomycosis — Toenail:

6 years or older: Apply to affected toenail(s) once a day for 48 weeks.

Comments:
-The integrated flow-through brush applicator should be used.
-The toenail, toenail folds, toenail bed, hyponychium, and undersurface of the toenail plate should be completely covered.

Use: For the topical treatment of onychomycosis of the toenail(s) due to T rubrum and T mentagrophytes

Detailed Jublia dosage information
What happens if I miss a dose?
Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?
An overdose of Jublia solution is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line if anyone has accidentally swallowed the medication.

What should I avoid while using Jublia?
Do not get this medicine in your eyes, mouth, or vagina. Jublia solution is for use only on the toenails.

Avoid having a pedicure or using nail polish on your toenails.

Jublia side effects
Get emergency medical help if you have signs of an allergic reaction to Jublia: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

severe redness, itching, or swelling of the affected toenail.

Common Jublia side effects may include:

pain, redness, swelling, burning, stinging, itching, or blisters where the medicine was applied; or

ingrown toenail.

What is ketoconazole topical?

Ketoconazole topical (for the skin) is an antifungal medicine used to treat infections such as athlete’s foot, jock itch, ringworm, and seborrhea (dry, flaking skin or dandruff).

Ketoconazole topical is also used to treat a fungal infection called pityriasis, which causes scaly discolored patches on the skin of the neck, chest, arms, or legs.

Ketoconazole topical may also be used for purposes not listed in this medication guide.

Ketoconazole topical side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Ketoconazole topical may cause serious side effects. Call your doctor at once if you have:

• burning, stinging, or severe irritation after using ketoconazole topical;
• redness, pain, or oozing of treated skin; or
• shortness of breath.

Common side effects of ketoconazole topical may include:

• thinning hair;
• changes in the color or texture of your hair;
• dry skin; or
• mild itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA .

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use ketoconazole topical if you are allergic to ketoconazole.

Ask a doctor or pharmacist if this medicine is safe to use if you have:

• asthma or a sulfite allergy;
• an allergic reaction to an antifungal medicine, such as clotrimazole, econazole, or miconazole.

Ask a doctor before using this medicine if you are pregnant.

You should not breast-feed while using ketoconazole topical.

Always follow directions on the medicine label about using this medicine on a child.

How should I apply ketoconazole topical?

Use exactly as directed on the label, or as prescribed by your doctor.

Using more of this medicine or applying it more often than prescribed will not make it work any faster, and may increase side effects.

Do not take by mouth. Topical medicine is for use only on the skin. Do not use on open wounds or irritated skin. Rinse with water if this medicine gets in your eyes, nose, or mouth.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Wash your hands before and after using this medicine.

Clean and dry the skin before applying ketoconazole cream, foam, or gel.

This medicine may be flammable. Do not use near high heat or open flame, or while smoking. Avoid heat or smoking until the medicine has completely dried on your skin.

Ketoconazole shampoo is not for daily use. Allow at least 3 days to pass between uses.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication.

Call your doctor if your symptoms do not begin to improve after 2 to 4 weeks of treatment, or if your condition gets worse.

Store ketoconazole topical at room temperature. Protect from light and do not refrigerate or freeze.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

An overdose of ketoconazole topical is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using ketoconazole topical?

Do not get ketoconazole topical in your eyes. If contact does occur, rinse with water.

Avoid covering treated skin areas with tight-fitting, synthetic clothing (such as nylon or polyester) that doesn’t allow air to circulate to your skin. If you are treating your feet, wear clean cotton socks and sandals or shoes that allow for air circulation. Keep your feet as dry as possible.

You may need to avoid sunlight if you are treating pityriasis. Follow your doctor’s instructions.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime.

Avoid using other medications on the areas you treat with ketoconazole topical unless your doctor tells you to.

What is nystatin topical?

Nystatin is an antifungal medication. Nystatin prevents fungus from growing on your skin.

Nystatin topical (for the skin) is used to treat skin infections caused by yeast.

Nystatin topical is not for use to treat a vaginal yeast infection.

Nystatin topical may also be used for purposes not listed in this medication guide.

Nystatin topical side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using nystatin topical and call your doctor at once if you have severe burning, itching, rash, pain, or other irritation where the medicine is applied.

Less serious side effects may include mild itching or irritation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Warnings

Do not use nystatin topical to treat any skin condition that has not been checked by your doctor.

Nystatin topical (for the skin) is not for use to treat a vaginal yeast infection.

Avoid getting this medication in your eyes or mouth. If this does happen, rinse with water.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.

Call your doctor if your symptoms do not improve, or if they get worse while using nystatin topical.

Do not share this medication with another person, even if they have the same symptoms you have.

Before taking this medicine

You should not use nystatin topical if you have ever had an allergic reaction to it.

FDA pregnancy category C. It is not known whether nystatin topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether nystatin topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use nystatin topical?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Do not use nystatin topical to treat any skin condition that has not been checked by your doctor.

Wash your hands before and after using this medication.

Clean and dry the skin before you apply nystatin topical.

Do not cover treated skin with bandages or dressings that do not allow air circulation unless your doctor tells you to.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.

Call your doctor if your symptoms do not improve, or if they get worse while using nystatin topical.

Do not share this medication with another person, even if they have the same symptoms you have.

Store at room temperature away from moisture and heat.

Nystatin topical dosing information

Usual Adult Dose for Cutaneous Candidiasis:

Apply nystatin topical cream, ointment or powder in a quantity sufficient to cover the affected area and immediately surrounding skin 2 to 4 times a day.

The powder formulation is useful for the treatment of moist areas or lesions.

Therapy should be continued for 2 to 8 weeks, depending on the nature and severity of the infection.

Usual Adult Dose for Vaginal Candidiasis:

Insert one nystatin vaginal tablet (100,000 units) vaginally once a day, preferably at bedtime, for a total of 14 days.

Usual Pediatric Dose for Cutaneous Candidiasis:

Apply nystatin topical cream, ointment or powder in a quantity sufficient to cover the affected area and immediately surrounding skin 2 to 4 times a day.

The powder formulation is useful for the treatment of moist areas or lesions.

Therapy should be continued for 2 to 8 weeks, depending on the nature and severity of the infection.

Usual Pediatric Dose for Vaginal Candidiasis:

>13 <18 years: Insert one nystatin vaginal tablet (100,000 units) vaginally once a day, preferably at bedtime, for a total of 14 days.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line .

What should I avoid while using nystatin topical?

Avoid getting this medication in your eyes or mouth. If this does happen, rinse with water.

Avoid wearing tight-fitting, synthetic clothing (such as nylon) that doesn’t allow air circulation. Wear clothing made of loose cotton and other natural fibers until your infection is healed.

What other drugs will affect nystatin topical?

It is not likely that other drugs you take orally or inject will have an effect on topically applied nystatin topical. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.