CD38 monoclonal antibodies 

Monoclonal antibodies used in immunotherapy are produced artificially from a cell clone therefore consist of a single type of immunoglobulin. They are targeted towards antigenic determinant on antigens and bind to form a complex which can be used for a specific purpose. CD38 monoclonal antibodies target the CD38 surface antigen of hematopoietic cells, which is important for cell function. Once CD38 monoclonal antibodies bind to the antigen it inhibits tumour growth by interrupting CD38 functions and causes cell death. CD38 monoclonal antibodies are used to treat multiple myeloma.

A substance that binds to a protein called CD38, which is found on some types of blood cells and in high levels on some cancer cells, including myeloma cells. Anti-CD38 monoclonal antibody may block the CD38 protein and help the immune system kill cancer cells.

CD38 is a multi-functional transmembrane protein that is a lymphocyte receptor and a clinical marker for survival of patients with B-cell chronic lymphocytic leukemia (CLL)