Coagulation modifiers 

What are Coagulation modifiers?

Coagulation modifiers are drugs that act on the blood coagulation pathway in different places to prevent or promote blood clot formation.

  • Anticoagulants and antiplatelet drugs are used to prevent blood clot formation.
  • Thrombolytic drugs (also called fibrinolytic drugs) are used to break up blood clots.
  • Heparin antagonists, anticoagulant reversal agents, and platelet-stimulating agents are used to reduce the risk of bleeding.

Coagulation modifiers are drugs that act on the blood coagulation pathway in different places to prevent or promote blood clot formation. Anticoagulants and antiplatelet drugs are used to prevent blood clot formation.

Coagulation consists of three pathways, the extrinsic, intrinsic, and common pathways, that interact together to form a stable blood clot. The extrinsic and intrinsic coagulation pathways both lead into the final common pathway by independently activating factor X.

Coagulants
DrugTargetType
ThrombinCoagulation factor Vtarget
ThrombinCoagulation factor VIIItarget
Tranexamic acidPlasminogentarget
VasopressinVasopressin V1a receptortarget

List of Coagulation modifiers