Diarylquinolines

What are Diarylquinolines?

Diarylquinolines are antimycobacterial drugs that interfere with mycobacterial energy production by binding and inhibiting subunit c of ATP synthase in the mycobacterium. The mycobactericidal activity is due to it being unable to generate energy. Diarylquinolines are used as part of combination therapy in pulmonary multi-drug resistant tuberculosis (MDR-TB) and usually administered as directly observed therapy (DOT).

Diaryl quinolines (DARQs) are a chemical class of drugs that treat tuberculosis. They target subunit c of mycobacterial ATP synthase, inhibiting the enzyme so mycobacterium tuberculosis cannot synthesise ATP. This effectively kills the bacteria.

Cholinesterase is a family of enzymes that catalyzes the hydrolysis of the neurotransmitter acetylcholine (ACh) into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation.

Bedaquiline is in a class of medications called anti-mycobacterials. It works by killing the bacteria that cause MDR-TB.

Calfactant adsorbs rapidly to the surface of the alveolar air:fluid interface and modifies surface tension to a minimum of less than 3 mN/m. It acts in a manner similar to natural lung surfactant, thus preventing or treating respiratory distress syndrome.