Antiadrenergic agents (central) with thiazides
What are Antiadrenergic agents (central) with thiazides?
Centrally acting antiadrenergic with thiazides is a combination medicine that contains both a centrally acting antiadrenergic agent with a thiazide diuretic. This combination is used to treat hypertension.
Centrally acting antiadrenergic agents block the andrenergic receptors in the central nervous system by reducing catecholamines release and effect. This causes the heart to beat slower with more force and the blood vessels to dilate which reduces blood pressure.
Thiazide diuretics decrease active re-absorption of sodium and chloride ions by inhibiting the sodium/chloride co-transporter in the distal convoluted tubule. They also increase potassium ion loss. Thiazide diuretics decrease the blood volume by diuresis and are used to decrease blood pressure.
Three thiazide diuretics are the most commonly used: hydrochlorothiazide (HCTZ), chlorthalidone, and indapamide. HCTZ and chlorthalidone are FDA-approved for clinical use in the management of primary hypertension.
Central-acting agents are medicines that lower heart rate and reduce blood pressure. They block the signals from the brain to the nervous system that increase the heart rate and narrow blood vessels. As a result, the heart does not pump as hard. Blood flows more easily through the body’s veins and arteries.





