Beta-lactamase inhibitors
What are Beta-lactamase inhibitors?
Beta-lactamases cleave the beta-lactam ring of susceptible penicillins and cephalosporins, inactivating the antibiotic. Some antimicrobials (eg, cefazolin and cloxacillin) are naturally resistant to certain beta-lactamases. The activity of the beta-lactams: amoxicillin, ampicillin, piperacillin, and ticarcillin, can be restored and widened by combining them with a beta-lactamase inhibitor.
Clavulanic acid, sulbactam, and tazobactam are all beta-lactamase inhibitors.
Beta-lactamase inhibitors are medications used ubiquitously in modern medicine due to their ability to combat bacterial antimicrobial resistance mechanisms. Antimicrobial resistance poses an enormous global public health challenge.
List of Beta-lactamase inhibitors
