Heparin antagonists
What are Heparin antagonists?
Heparin antagonists are substances which inhibit the anticoagulant action of heparin. They may be used for the treatment of severe heparin overdosage.
A heparin antagonist is a substance, such as protamin, that is used to counteract the effects of heparin overdose by forming an insoluble complex with heparin.
Protamine is a medication used to reverse and neutralize the anticoagulant effects of heparin. Protamine is the specific antagonist that neutralizes heparin-induced anticoagulation.
| Drug Name | Avg. Rating | Reviews |
|---|---|---|
| enoxaparin systemic (Pro) Brand name: Lovenox | 6.8 | 26 reviews |
| dalteparin systemic (Pro) Brand name: Fragmin | 6.0 | 5 reviews |
| heparin systemic (Pro) Brand name: Heparin Sodium | 1.0 | 2 reviews |
| heparin flush systemic Brand name: Monoject Prefill Advanced | No reviews |
In case of emergency bleeding, in response to heparin overdose or during heart surgery, protamine sulphate is administered as antidote. Despite its extensive clinical use, protamine may produce life-threatening side effects such as systemic hypotension, catastrophic pulmonary vasoconstriction or allergic reactions.
List of Heparin antagonists





