Lincomycin derivatives

What are Lincomycin derivatives?

Lincomycin derivatives are a small group of antibiotics that inhibit synthesis of bacterial proteins, essential for bacteria to survive. Lincomycin derivatives are reserved for treatment of infections due to susceptible strains of pneumococci, staphylococci and streptococci. One derivative is also indicated for treatment of Plasmodium falciparum (malaria).

Clindamycin, a semisynthetic derivative of lincomycin, is an antibiotic effective against gram positive aerobes and anaerobes, and gram negative anaerobes. The capsule preparation is a hydrochloride salt, the oral solution is the palmitate hydrochloride salt, and the intravenous preparation is the phosphate salt.

Lincomycin is a lincosamide antibiotic derived as a natural fermentation product from Streptomyces lincolnensis.

Lincomycin—(Lincocin; Lincoject; Lincorex; L-Mycin)
There are 2 main antibiotics in the lincosamide family: lincomycin and clindamycin. Because lincomycin has been associated with severe colitis that may end fatally, it should be reserved for serious infections where less toxic antimicrobial agents are ineffective.

IgG – Immune defense and passive immunity. IgM – Early response and complement activation. IgA – Mucosal protection and neonatal defense. IgE – Allergies and parasite defense. IgD – B and T cell regulation.

Globulins are a group of proteins in your blood. Some globulins are made by your liver. Others are made by your immune system. Globulins play an important role in liver and kidney function, blood clotting, and fighting infection.