Macrolide derivatives

What are Macrolide derivatives?

Macrolide derivatives are either macrolide antibiotics or other antibiotics related to macrolides.

Macrolides are a class of antibiotics found in streptomycetes. They are natural lactones with a large ring, consisting of 14 to 20 atoms. Macrolides bind to the 50S subunit of the bacterial ribosome and inhibit ribosomal translocation, leading to inhibition of bacterial protein synthesis. Their action is primarily bacteriostatic but may be bactericidal at high concentrations, or depending on the type of microorganism.

What are Macrolide derivatives? Macrolide derivatives are either macrolide antibiotics or other antibiotics related to macrolides. Macrolides are a class of antibiotics found in streptomycetes. They are natural lactones with a large ring, consisting of 14 to 20 atoms.

Macrolides are a class of antibiotics derived from Saccharopolyspora erythraea(originally called Streptomyces erythreus), a type of soil-borne bacteria. Macrolides inhibit protein synthesis in bacteria by reversibly binding to the P site of the 50S unit of the ribosome.

Azithromycin and clarithromycin are derivatives of the older macrolide antibiotic erythromycin. They are used in the treatment of a variety of infections, including community-acquired respiratory tract infections and mycobacterial infections.