Succinimide anticonvulsants 

What are Succinimide anticonvulsants?

Succinimide anticonvulsants are thought to increase the seizure threshold, inhibit T-type calcium channels and inhibit the three-cycle per second thalamic ‘spike and wave’ discharge in absence seizures. Succinimide anticonvulsants are mostly used to treat absence seizures.

Succinimides refer to a class of drugs that are primarily used in the treatment of absence seizures, a type of epilepsy. The most commonly used succinimide is ethosuximide, which is effective and relatively safe for absence seizures. Other drugs in this class include phensuximide and methosuximide.

Generic and brand names of succinimide anticonvulsants include:
  • Celontin.
  • Ethosuximide.
  • Methsuximide.
  • Zarontin.

Succinimide anticonvulsants are thought to increase the seizure threshold, inhibit T-type calcium channels and inhibit the three-cycle per second thalamic ‘spike and wave’ discharge in absence seizures. Succinimide anticonvulsants are mostly used to treat absence seizures.

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List of Succinimide anticonvulsants