Topical depigmenting agents

What are Topical depigmenting agents?

Topical depigmenting agents work in different ways to inhibit melanogenesis (the pigmentation pathway by which cells produce melanin). Some agents cause reversible depigmentation and some cause irreversible depigmentation. These agents are applied on the skin, on the affected area to treat hyperpigmentation.

Commonly used depigmenting agents include , arbutin, azelaic acid, kojic acid, ascorbic acid and resveratrol. Hydroquinone was considered to be the gold standard to treat acquired pigmentary disorders, particularly melasma.

Depigmenting agents are topical lightening agents used for skin disorders associated with hyperpigmentation and melasma (a condition that causes dark, discolored patches on your skin).

To remove color from your skin, dermatologists prescribe a medication called monobenzone. You apply this medication twice a day to pigmented areas of skin. Gradually, this medication causes pigmented areas to fade, eventually matching the lighter patches of skin caused by vitiligo.

Monobenzyl ether of hydroquinone (MBEH) is a hydroquinone derivate, also known as monobenzone or by its chemical name, p-(benzyloxy) phenol. At present, it is the most potent depigmenting agent and the mainstay of depigmentation therapy.

What is a depigmenting cream? The basic definition is that it is a topical solution with ingredients that can regulate the visible action of the enzyme tyrosinase. This enzyme catalyses the production of melanin, which is the pigment responsible for the skin’s colour, hyperpigmentation and blemishes.