Hydantoin anticonvulsants 

Hydantoin anticonvulsants are structurally related to barbiturates. They have an allantoin heterocyclic base. Hydantoins slow the synaptic transmission by blocking sodium channels from recovering from the inactivated state, and inhibits neurons from firing. This stops the repeated excitation of cells that results in seizures.

Hydantoin anticonvulsants are used to treat a wide range of seizures types.

Hydantoin (2,4-Imidazolidinedione Glycolylurea), is an heterocyclic organic compoundthat has anticonvulsant properties and is used as treatment for seizure disorders or as muscle relaxant in drug intoxication associated problems (Donald and Easton, 1972).

The hydantoin group can be found in several medicinally important compounds. In pharmaceuticals, hydantoin derivatives form a class of anticonvulsants; phenytoin and fosphenytoin both contain hydantoin moieties and are both used as anticonvulsants in the treatment of seizure disorders.

A hydantoin antiepileptic used to control tonic-clonic and complex partial seizures. An antiepileptic agent used for the management of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery. A phenylhydantoin used to treat refractory partial epilepsy.