NK1 receptor antagonists

What are NK1 receptor antagonists?

Neurokinin-1 (NK1) receptor antagonists are used for prevention of acute and delayed nausea and vomiting. The NK1 receptor antagonist competitively binds to the NK1 receptor, which blocks the binding of substance P and prevents the emetic signal being transmitted. NK1 receptor antagonists can be used in conjunction with 5-HT3-receptor antagonists and corticosteroids to augment their antiemetic activity.

Neurokinin-1 Receptor Antagonists
Two formulations are available, aprepitant (oral) and fosaprepitant (parenteral), and several others (e.g., casopitant, vestipitant, netupitant) are undergoing evaluation.

List of NK1 receptor antagonists

Drug Name	Avg. Rating	Reviews
aprepitant systemic (Pro) Brand names: Aponvie, Cinvanti, Emend	8.0	18 reviews
rolapitant systemic (Pro) Brand name: Varubi	10	1 review
fosaprepitant systemic (Pro) Brand names: Emend for Injection, Focinvez		1 review

The other analgesics, such as acetaminophen or ibuprofen, typically found in narcotic analgesic combinations mainly work by inhibiting enzymes called cyclo-oxygenase (COX) enzymes that produce prostaglandins. Prostaglandins promote inflammation, pain and fever.

Antagonist drugs interfere in the natural operation of receptor proteins. They are sometimes called blockers; examples include alpha blockers, beta blockers, and calcium channel blockers.