Renin inhibitors

What are Renin inhibitors?

Renin inhibitors block the activity of renin and cause vasodilatation. Renin is an enzyme that converts angiotensinogen to angiotensin I, which is then converted to angiotensin II by angiotensin converting enzyme. Angiotensin II is a potent vasoconstrictor that causes the blood pressure to rise.

Renin inhibitors are used to treat hypertension.

Renin inhibitors are pharmaceutical drugs inhibiting the activity of renin that is responsible for hydrolyzing angiotensinogen to angiotensin I, which in turn reduces the formation of angiotensin II that facilitates blood pressure.

Renin Inhibitors

Drug	Drug Description
Enalkiren	Not Available
VTP-27999	VTP-27999 has been used in trials studying the basic science of Renal Function.
Remikiren	For the treatment of hypertension and heart failure
Aliskiren	A direct renin inhibitor used to manage hypertension.

Renin–angiotensin–aldosterone system (RAAS) inhibitors are the key medications for patients with heart failure and chronic kidney disease. Multiple randomized controlled trials have demonstrated their benefits in an outpatient setting for the treatment of chronic heart failure.

ACE inhibitors and RIs inhibit the RAS but have different sites of action; ACE inhibitors inhibit the conversion of angiotensin I to angiotensin II, while the RIs block enzymatic action of renin, the conversion of angiotensinogen to angiotensin I.