Aminosalicylates
What are Aminosalicylates?
Aminosalicylates or aminosalicylic acid is used with other drugs to treat tuberculosis. Aminosalicylic acid is thought to inhibit folic acid synthesis and/or inhibit synthesis of a component of the cell wall. It is bacteriostatic against Mycobacterium tuberculosis. Aminosalicylates also prevent development of bacterial resistance to drugs such as streptomycin and isoniazid.
The aminosalicylates may maintain remission in inflammatory bowel disease by preventing leucocyte recruitment into the bowel wall. The drugs inhibit the chemotactic response to leukotriene B4, reduce the synthesis of platelet activating factor and also inhibit leucocyte adhesion molecule upregulation.
Examples of these medications include mesalamine, sulfasalazine, and olsalazine. You might recognize them as the brand names Salazopyrin®, Mezavant®, Pentasa®, Salofalk®, and Teva®.





